top of page

Dr. Stéphane Canaan
Team leader

X.png

Follow us on X

Stéphane Canaan

We aim at deciphering the physiological role of lipolytic enzymes involved in lipid metabolism in pathogenic mycobacteria (such as Mycobacterium tuberculosis, M. abscessus, M. marinum, M. ulcerans), their regulation during the infection process; and to develop specific models to study these enzymes and their inhibitors in order to regulate the spread of the disease.

We have indeed established that these enzymes are involved in bacterial growth, virulence (reactivation and propagation), dormancy, lipid storage and degradation as well as in cell wall biosynthesis. Moreover, our work leads to the discovery of two new family of lipolytic enzyme inhibitors with strong anti-tuberculous effects, and which are useful probes to study mycobacterial lipid metabolism, thus opening a new way to fight the disease.

The team expertise range from protein biochemistry (purification, biochemical characterization, expression of recombinant protein using E. coli, M. smegmatis, P. Pastoris or baculovirus expression systems), molecular and cell biology (construction of mutant strains, cell infection), lipid analysis to medicinal chemistry (organic synthesis, in silico docking, enzymology, susceptibility testing...) and cell imaging (fluorescence and electron microscopy).

smeg GFP LBP.png

! Two positions available at Aix-Marseille Univ. !
Contact us for more information

UPCOMING EVENTS

GRC Tuberculosis Drug Discovery and Development

Castelldefels, Spain - July 20-25, 2025
GRC New Antibacterial Discovery and Development

Ventura, United States - March 17-22, 2024
19th National Congress of the SFM

Lille, France - October 7-9, 2024
8th International Symposium on Antimicrobial Peptides

Marseilles, France - June 5-7, 2024

THE TEAM LATEST RESEARCH

bottom of page