Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems Point, V., Achache, W., Laudouze, J., Sepulveda Ramos, E., Maziero, M., Crauste, C., Canaan, S. and Santucci, P. The genetic basis underlying nontuberculous mycobacteria (NTM) pathogenesis remains poorly understood. This gap in knowledge has been partially filled over the years through the generation of novel and efficient genetic tools, including the r

Bioactive Compounds Discovery from French Guiana Plant Extracts Through Antitubercular Screening and Molecular Networking Breaud, C.; Saunier, C.; Baghdikian, B.; Mabrouki, F.; Bertolotti, M.; Royer, M.; Silland, P.; Maresca, M.; Garaev, E.; Cavalier, J.-F.; Canaan, S.; Bun-Llopet, S.-S.; Garayev, E. Tuberculosis (TB) is still a significant public health threat, with rising drug resistance and high incidence in multiple areas worldwide. In the search for novel antitubercular

The polyamino-isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi-target inhibitors against the ESKAPEE...

Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based...

Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium...

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms Laudouze, J.; Canaan, S.; Gouzy, A.; Santucci, P. ...

Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous...

A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria Dargham, T.; Aguilera-Correa, J.J.; Avellan,...

A dTDP-L-rhamnose 4-epimerase required for glycopeptidolipid biosynthesis in Mycobacterium abscessus Aguilera-Correa, J.J.; Wei, F.; Leclercq, L.D.; Tasrini, Y.; Mullapudi, E.; Daher, W.; Nakajima, K.; Canaan, S.; Herrmann, J.L.; Wilmanns, M.; Guérardel, Y.; Wen, L.; Kremer, L. Mycobacterium abscessus  causes severe lung infections in cystic fibrosis patients and exhibits smooth (S) or rough (R) morphotypes. Disruption of glycopeptidolipid (GPL) production results in the S-to

Antitubercular potential and pH-driven mode of action of salicylic acid derivatives Laudouze, J.; Francis, T.; Forest, E.; Mies, F.; Bolla, J.M.; Crauste, C.; Canaan, S.; Shlyonsky, V.; Santucci, P.; Cavalier, J.-F. In the search for new antituberculosis drugs with novel mechanisms of action, we evaluated the antimycobacterial activity of a panel of eight phenolic acids against four pathogenic mycobacterial model species, including Mycobacterium tuberculosis . We demonstrated