A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria Dargham, T.; Aguilera-Correa, J.J.; Avellan,...

A dTDP-L-rhamnose 4-epimerase required for glycopeptidolipid biosynthesis in Mycobacterium abscessus Aguilera-Correa, J.J.; Wei, F.; Leclercq, L.D.; Tasrini, Y.; Mullapudi, E.; Daher, W.; Nakajima, K.; Canaan, S.; Herrmann, J.L.; Wilmanns, M.; Guérardel, Y.; Wen, L.; Kremer, L. Mycobacterium abscessus causes severe lung infections in cystic fibrosis patients and exhibits smooth (S) or rough (R) morphotypes. Disruption of glycopeptidolipid (GPL) production results in the S-to

Antitubercular potential and pH-driven mode of action of salicylic acid derivatives Laudouze, J.; Francis, T.; Forest, E.; Mies, F.; Bolla, J.M.; Crauste, C.; Canaan, S.; Shlyonsky, V.; Santucci, P.; Cavalier, J.-F. In the search for new antituberculosis drugs with novel mechanisms of action, we evaluated the antimycobacterial activity of a panel of eight phenolic acids against four pathogenic mycobacterial model species, including Mycobacterium tuberculosis . We demonstrated

Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus Sarrazin,...

Fluorescence-based CRISPR interference system for controlled genetic repression and live single-cell imaging in mycobacteria Laudouze, J.; Point, V.; Achache, W.; Crauste, C.; Canaan, S.; Santucci, P. In this research letter, we report the development and validation of a new subset of fluorescence-based CRISPR interference (CRISPRi) tools for our scientific community. The pJL series is directly derived from the original pIRL CRISPRi vectors and conserves all the elements to p

Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities Di Maio, A.; Olleik, H.; Courvoisier-Dezord, E.;...

Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus Casanova, M.;...

Intrabacterial lipid inclusion-associated proteins: A core machinery conserved from saprophyte Actinobacteria to the human pathogen...

Host cell environments and antibiotic efficacy in tuberculosis Day, N.J..; Santucci, P.; Gutierrez, M.G. The aetiologic agent of...

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages Pellegrino, E.; Aylan, B.; Bussi, C.;...