J Lipid Res (2026) 67(8): 101098. https://doi.org/10.1016/j.jlr.2026.101098
Reevaluation of mycobacterial phosphatidyl-myo-inositol mannosides (PIMs) as Toll-like receptor 2 (TLR2) agonists Belkai, S.; Carrat, C.; Layre, E.; Cala-De Paepe, D.; Vercellone, A.; Blanc, L.; Dessaux, C.; Chanchabi, C.; Stella, S.; Burlet-Schiltz, O.; Canaan, S.; Vergne, I.; Nigou, J.; Gilleron, M. Toll-like receptor 2 (TLR2) is a key pattern recognition receptor in the innate immune detection of Mycobacterium tuberculosis (Mtb). TLR2 has been shown to recognize not only l






