High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages Aylan, B.; Botella, L.; Gutierrez, M. G.; Santucci, P. Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) have evolved diverse strategies to counteract macrophage defence mechanisms including phagolysosomal biogenesis. Within macrophages, Mtb initially resides inside membrane-bound phagosomes that interact with lysosomes and become

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